Ngomhla ka-9 Novemba 2021, okuhlukile kwei-coronavirus entshaI-B.1.1.529 itholwe okokuqala kwisampula yecala laseNingizimu Afrika.Esikhathini esingaphansi kwamaviki ama-2, uhlobo oluguquguqukayo lwaba uhlobo olunamandla oluguquguqukayo lwezigameko ezintsha zokutheleleka komqhele eNingizimu Afrika, futhi ukukhula kwalo ngokushesha sekuvuse ukunakwa komhlaba wonke.Ngomhla zingama-26 kuLwezi, lolu hlobo oluguquguqukayo luchazwe yi-WHO “njengokwesihlanu “okuhlukile kokukhathazeka” (VOC), okuqanjwe ngokuthi i-Omicron (Omicron) mutant.Njengamanje, uhlobo oluhlukile lwe-Omicrom selusabalale ngokushesha emazweni noma ezifundeni eziyi-19 emhlabeni jikelele, futhi lungase luveze umjikelezo omusha wezinselelo ezinzima ekuvimbeleni nasekulawuleni ubhubhane lomhlaba wonke.
I-WHO iphinde yathi i-Omicron inenani elikhulu lezinguquko, ezinye zazo ezikhathazayo.I-WHO iphinde yathi uhlobo oluguquguqukayo lwe-“Omicron” lutholwa ngokushesha kunezinye izinhlobo eziguquguqukayo ezibangele ukwanda kwezifo esikhathini esidlule, okubonisa ukuthi lolu hlobo lwakamuva oluguquguqukayo lungaba nethuba lokukhula.Ukuvimbela ngokuqinile ukusabalala kohlobo oluguquguqukayo lwe-coronavirus entsha I-Omicron isiphenduke into entsha okuhloswe ngayo ukuvimbela ubhubhane lomhlaba wonke.
Imephu yokusabalalisa yokuguqulwa kwe-Omicron(1）kanye neDelta(2）, I-Stanford University Coronavirus kanye neDathabase Resistance Database
Ngaphezu kokuba nezinguquko eziningi kuphrotheni ye-spike, uhlobo lwe-Omicron mutant luphinde lube nezindawo eziningi zokuguqula iphrotheni engu-N.Njengoba okuhlosiwe okuyinhloko kwe-reagent entsha yokutholwa kwe-coronavirus antigen kuyiphrotheni engu-N, ukuguqulwa kwephrotheni i-N kungase kuthinte i-antigen entsha ye-coronavirus.Ukunemba kwekhithi yokuhlola kunomthelela.
| Ithebula 1. Ukuqhathaniswa kwe-N protein evolution yezinhlobo ezahlukene zezakhi eziguquliwe
| |
| Uhlobo lwegciwane
| N amaprotheni evolution |
| I-Alpha(B.1.1.7) | R203K;I-G204R;(>50%) I-S194L(5-50%) D3H;D63G;T205I;M234I(1-5%) |
| I-Beta(B.1.351) | I-T205I (>50%) I-P13S;T3621(5-50%) Q9H;Q28R;A35T;E38V;Q418H (1-5%) |
| I-Gamma(p.1) | P80R;S202C;R203K;G204R (>50%) I-A211S;D402Y;S4131 (1-5%) |
| I-Delta(B.1.617.2) | I-D63G;R203M;G215C;D377Y (>50%) I-Q9L(>5-50%) I-G18V;R385K (1-5%)
|
| I-Omicron(B.1.1.529) | I-P13L;R203K;G204R E31/R32/S33 Del |
Uma kuqhathaniswa nephrotheni ye-Alpha-N, iphrotheni ye-Omicron-N inomehluko wezikhundla ze-amino acid eziyi-10.Ukuze kuphenywe ukusebenza kokutholwa kwephrotheni ye-Omicron-N nge-antibody ye-covid-19 yezakhi zofuzo ze-Keygen, silungise iphrotheni ye-Omicron-N ehlanganisiwe okokuqala ngqa , Futhi senza ukuqinisekiswa okuhlanganyelwe yi-Keygen Gene kanye nedlanzana lamakhasimende.Imiphumela ibonisa ukuthi ufuzo olusha lokubuka olusha lwe-antibody lunemiphumela efanayo yokutholwa kwephrotheni ye-Omicron-N ehlanganisiwe, iphrotheni ye-Alpha-N kanye nephrotheni ye-Delta-N.I-open view gene entsha yezinto ezivikela amasosha omzimba ingaqinisekisa ukunemba kwekhithi ye-antigen yegciwane lomqhele ukuze kutholwe okuhlukile kwe-Omicron..
| Ithebula 2 Imiphumela yokutholwa kwe-Omicron recombinant N protein nge-neocorona antibody | ||||||
| I-antibody Kubhanqiwe | I-Alpha-Nprotein | I-Omicron-Nprotein | ||||
| 4.0ng/ml | 2.0ng/ml | 1.0ng/ml | 4.0ng/ml | 2.0ng/ml | 1.0ng/ml | |
| Uhlelo 1 | G5 | G4 | G2 | G5 | G4 | G2 |
| Uhlelo 2 | G5 | G4 | G2 | G5 | G4 | G2 |
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Isikhathi sokuthumela: Dec-14-2021
