Kunezinhlobo eziningi ze-serum, njenge-fetus bovine serum, i-calf serum, i-serum yembuzi, i-serum yamahhashi, njll. Izinga le-serum linqunywa ikakhulukazi into kanye nenqubo yesampula.Izilwane ezisetshenziselwa ukuqoqa impahla kufanele zibe nempilo futhi zingabi nezifo futhi zingakapheli izinsuku zokuzalwa ezishiwo.Inqubo yokuqoqa impahla kufanele yenziwe ngokuhambisana ngokuqinile nezinqubo zokusebenza, futhi i-serum elungisiwe kufanele ibe ngaphansi kokuhlonza ikhwalithi eqinile.Okudingekayo kokuthi "Izinqubo zokukhiqizwa kwemikhiqizo yebhayoloji ngesiko le-in vitro lamaseli ezilwane" eshicilelwe yi-WHO:

1. I-serum yezinkomo kufanele ivele emhlambini noma ezweni elibhalwe ukuthi alinayo i-BSE.Futhi kufanele ibe nesistimu yokuqapha efanele.
2. Amanye amazwe adinga futhi i-serum yezinkomo emihlambini engazange inikezwe amaprotheni ane- ruminant.
3. Kwaboniswa ukuthi i-serum yezinkomo esetshenzisiwe ayinawo ama-inhibitors egciwaneni lokugoma elikhiqizwayo.
4. I-Serum kufanele ihlanzwe ngokuhlunga ngolwelwesi lwesihlungi ukuze kuqinisekiswe ubunyumba.
5. Akukho ukungcoliswa kwebhaktheriya, isikhunta, i-mycoplasma kanye negciwane, amanye amazwe awadingi ukungcoliswa kwe-bacteriophage.
6. Inokwesekwa okuhle kokukhiqizwa kwamaseli.