I-IVD reagent material Umaka wenhliziyo

I-Cardiac Troponin I (cTnI) iwuhlobo oluncane lomndeni we-troponin oluvame ukusetshenziswa njengophawu lokulimala kwe-myocardial.I-Cardiac troponin I iqondene ngqo nezicubu zenhliziyo futhi itholakala ku-serum kuphela uma kwenzeka ukulimala kwe-myocardial.Ngenxa yokuthi i-cardiac troponin I iyinkomba ebucayi kakhulu futhi ethize yokulimala kwemisipha yenhliziyo (i-myocardium), amazinga e-serum angasetshenziswa ukusiza ukuhlukanisa phakathi kwe-angina engazinzile kanye ne-myocardial infarction (ukuhlasela kwenhliziyo) kubantu abanezinhlungu zesifuba noma i-acute coronary syndrome.

I-isoform yenhliziyo ye-TnT isetshenziswa kakhulu njengophawu lokulimala kweseli le-myocardial, njengoba injalo i-cTnI.I-cTnT ine-kinetics yokukhululwa efanayo emgudwini wegazi kanye nokuzwela okufanayo kokulimala okuncane kwe-myocardial njenge-cTnI.Egazini leziguli ze-acute myocardial infarction (AMI), i-cTnT ivamise ukutholakala isesimweni samahhala kuyilapho i-cTnI itholakala kakhulu eyinkimbinkimbi ne-TnC.

I-Troponin C, eyaziwa nangokuthi i-TN-C noma i-TnC, iyiphrotheni ehlala ku-troponin complex ku-actin emincane emincane yemisipha e-striated (inhliziyo, uhlaka lwamathambo olusheshayo, noma uhlaka lwamathambo oluhamba kancane) futhi inesibopho sokubopha i-calcium ukuze isebenze. ukufinyela kwemisipha.I-Troponin C ibhalwe ngekhodi isakhi sofuzo se-TNNC1 kubantu kokubili kwenhliziyo nemisipha yamathambo ehamba kancane.

i-myoglobin iyiphrotheni ye-cytoplasmic ebopha umoya-mpilo eqenjini le-heme.Ineqembu elilodwa kuphela le-globulin, kanti i-hemoglobin inamane.Nakuba iqembu layo le-heme lifana nalawo aku-Hb, i-Mb inokuhlobana okuphakeme komoya-mpilo kune-hemoglobin.Lo mehluko uhlobene nendima yawo ehlukile: kuyilapho i-hemoglobin ihambisa umoya-mpilo, umsebenzi we-myoglobin uwukugcina umoya-mpilo.

I-Digoxin isetshenziselwa ukwelapha ukuhluleka kwenhliziyo, ngokuvamile kanye neminye imithi.Ibuye isetshenziselwe ukwelapha izinhlobo ezithile zokushaya kwenhliziyo okungajwayelekile (njenge-fibrillation ye-atrial engapheli).Ukwelapha ukuhluleka kwenhliziyo kungase kusize ugcine ikhono lakho lokuhamba nokuzivocavoca futhi kungase kuthuthukise amandla enhliziyo yakho.Ukwelapha ukushaya kwenhliziyo okungajwayelekile nakho kungathuthukisa ikhono lakho lokuzivocavoca.I-Digoxin ingeyeqembu lemithi ebizwa ngokuthi i-cardiac glycosides.Isebenza ngokuthinta amaminerali athile (i-sodium ne-potassium) ngaphakathi kwamaseli enhliziyo.Lokhu kunciphisa ukucindezeleka kwenhliziyo futhi kuyisize igcine ukushaya kwenhliziyo okuvamile, okuzinzile, nokunamandla.

CK-MB ku-acute myocardial infarction (AMI), kanye ne-CK-BB ekulimaleni kobuchopho kanye nesimila esiyingozi sepheshana le-gastro-intestinal.I-CK-MB ikalwa ngomsebenzi we-enzyme noma ukugxiliswa kwesisindo esiningi futhi ikalwa njengomaka hhayi kuphela ekuxilongweni kwe-AMI kodwa naku-AMI okusolekayo kanye ne-angina engazinzile.

I-heart-type-Fatty-Acid-Binding-Protein (hFABP) iyiphrotheni, ebandakanyeka ekuthuthweni kwe-intracellular myocardial (Bruins Slot et al., 2010; Reiter et al., 2013).Ngemuva kwe-myocardial necrosis i-hFABP idedelwa ngokushesha emgudwini wegazi futhi ngenxa yalokho yaphenywa njenge-biomarker ye-AMI.Kodwa-ke, ngenxa yokuzwela okuphansi kanye nokucaciswa kwe-hFABP akuzange kutholakale ukuthi iwusizo, uma kuqhathaniswa nokusebenza kokuxilonga kwe-hs-Tn assays (Bruins Slot et al., 2010; Reiter et al., 2013).

I-Lipoprotein-Associated Phospholipase A2(Lp-PLA2)

Ama-lipids angamafutha egazini lakho.Ama-Lipoprotein ayinhlanganisela yamafutha namaprotheni athwala amafutha egazini lakho.Uma une-Lp-PLA2 egazini lakho, ungase ube namadiphozi amafutha emithanjeni yakho esengozini yokuqhekeka futhi ibangele isifo senhliziyo noma unhlangothi.

I-D-dimer (noma i-D dimer) iwumkhiqizo wokuwohloka kwe-fibrin (noma i-FDP), ingxenye encane yamaprotheni ekhona egazini ngemva kokuba ihlule legazi lonakaliswe yi-fibrinolysis.Iqanjwe kanjalo ngoba iqukethe izingcezu ezimbili zika-D zeprotheni ye-fibrin ehlanganiswe isixhumanisi.